MIS ICH
Minimally Invasive Surgery for Intracerebral Hemorrhage (MIS ICH) Consensus Conference
Supported in part by NINDS award 1R13NS145667
Thank you to all who participated in the Minimally Invasive Surgery Intracerebral Hemorrhage Consensus Conference held in Baltimore, Maryland at Johns Hopkins University on July 26, 2025.
The MIS ICH Consensus Conference convened a wide-ranging and comprehensive group of field-leading experts as well as the stroke community at large to define the specific discoveries needed to produce level one evidence regarding the possible value of MIS.
Our internationally recognized key opinion leaders and trialists across the full spectrum of current and past pivotal ICH trials facilitated discussion with the goal of defining what is needed to promote practice change in utilizing MIS for ICH patients.
Conference leaders are currently drafting a white paper summarizing the key discussions and consensus points from the conference, and we look forward to sharing the publication with all attendees once it is finalized.
Program Agenda and Speakers
| Registration & Continental Breakfast | 7 a.m. |
| Welcome | Andrew Mould & Nichol McBee |
Session 1: Unanswered Questions in Intracerebral Hemorrhage
| State of ICH Care & Presurgical Pathway | Paul Vespa |
| Intracerebral Hemorrhage: Public Health Burden | Farhaan Vahidy |
| Polling | |
| Trial Endpoints & Subgroup Priorities | Dan Hanley |
| Panel Discussion and Q&A | Moderator: Farhaan Vahidy |
Session 2: Standardizing Surgical Deliverables for Differing Surgical Techniques
| Tools & Techniques for Minimally Invasive Evacuation of ICH | Geoff Colby |
| MIND | Babak Jahromi |
| Standardizing the Surgical Task in ICH Evacuation Trials | Mark Harrigan |
| Minimally Invasive Surgery and Realtime Imaging | Sean Polster |
| Panel Discussion and Q&A | Moderator: Mark Harrigan |
Break
Session 3: Standardizing Pre- and Post- Op Care
| Standardizing the ICH Presurgical Pathway | Paul Vespa |
| Optimal Prevention of Thrombosis after Intracerebral hemorrhage with intensive Medical therapy and Antiplatelet medications (OPTIMA) | Santosh Murthy |
| Follow-up Care – REASSESS | Wendy Ziai |
| Panel Discussion and Q&A | Moderator: Wendy Ziai |
Lunch will be served just outside the auditorium
Session 4: Answering Biological Questions
| Using MIS to Understand Inflammation in the Brain: A Focus on Macrophages | Lauren Sansing |
| Neuroprotection – SGL2 | Jarek Aronowski |
| Mechanistic Biomarkers of ICH: Causes and Effects | Issam Awad |
| Panel Discussion and Q&A | Moderator: Lauren Sansing |
Session 5: Funding Perspective MIS Trials Design
| NIH National Institute of Neurological Disorders and Stroke/StrokeNet | Scott Janis |
| PCORI Overview | Godfrey Woelk |
| Panel Discussion and Q&A | Moderator: Issam Awad |
Break
Session 6: Knowledge Gaps From Prior Trials: 10 Result and 10 Knowledge Gap
| Rapid Evacuation and Access of Cerebral Hemorrhage Trial | Alex Hall & Jonathan Ratcliff |
| Early ICH Treatment – MINUTE | Chris Kellner |
| Lessons From the FASTEST Trial | Joseph Broderick |
| Minimally Invasive Surgery for Intracerebral Hemorrhage (MIS ICH) | Dan Hanley |
| Knowledge Gap Panel Discussion and Q&A | Moderator: Sean Polster |
| Consensus Voting | Moderators: Wendy Ziai, Issam Awad, Sean Polster |
| Closing Remarks | Wendy Ziai |
| Adjourn | 5:30 p.m. |
Conference Leadership
Nichol McBee, MPH, ACRP-CP, MPI
- Research Associate, Department of Neurology
- Executive Director, BIOS Clinical Trials Coordinating Center
- Faculty Program Lead, JHU ICTR Trial Innovation Unit (TIU)
- Director, Johns Hopkins University Trial Innovation Center (JHU TIC)
Andrew Mould, MPH, MPI
- Assistant Professor, Department of Neurology
- DCC Director, BIOS Clinical Trials Coordinating Center
- HEAL Director, JHU SSRC HEAL Pain ERN
- Assistant Director, Johns Hopkins University Trial Innovation Center (JHU TIC)
Daniel Hanley, MD, Co-Investigator
- Director, BIOS Clinical Trials Coordinating Center
- PI, Johns Hopkins University Trial Innovation Center
- Deputy Director for Support and Innovation in Multicenter Trials, Johns Hopkins Institute for Clinical and Translational Research
- Jeffrey and Harriet Legum Professor of Acute Care Neurology
- Professor of Neurology, Neurosurgery, and Anesthesiology/Critical Care Medicine, Johns Hopkins University School of Medicine
Karen Lane, CMA, CCRP, Co-Investigator
- Assistant Professor of Neurology
- Deputy Director, BIOS Clinical Trials Coordinating Center
- Director, Multicenter Study Operations Training Program, ICTR
- MPI, Johns Hopkins University Trial Innovation Center
Wendy Ziai, MD, MPH, Co-Investigator
- Assistant Professor of Neurology, Neurosurgery, and Anesthesia/Critical Care Medicine, Johns Hopkins University School of Medicine
- Medical Director, Neurovascular Laboratory
- Co-Director, Johns Hopkins Bayview Neurocritical Care Unit